Pdf performance of the new slicc classification criteria. The systemic lupus international cooperating clinics slicc 2012 criteria increased sensitivity, but at the price of reduced specificity. Katarzyna gilekseibert, md abstract systemic lupus erythematosus sle is a chronic, compli cated and challenging disease to diagnose and treat. Comparison of sensitivities of american college of. Nossentthe influence of the 1997 updated classification criteria for systemic lupus erythematosus. The new criteria, which are on track for formal endorsement before the end of 2018 by the two medical societies that sponsored the revision, instead use a point system. The first classification criteria for sle were developed in 1971, revised in 1982, and adopted by the american college of rheumatology acr in 1997. Evaluation of the acr and slicc classification criteria in. Slicc 12 criteria are more effectiveness than acr 97 score about.
Derivation and validation of systemic lupus international. In 2012, the systemic lupus international collaborating clinics slicc presented a new classification for systemic lupus erythematosus sle. This study aims to compare the performance among the american college of rheumatology acr 1997, the systemic lupus international collaborating clinics criteria slicc and the new european league against rheumatism eularacr criteria, in a csle cohort. Until now, classification of systemic lupus erythematosus sle was a yesorno decision, based on whether the patient had a minimum number of characteristic signs or symptoms. This article provides more detail on the differences between classification and diagnostic criteria, and why the.
The systemic lupus international collaborating clinics slicc damage index. Validation of the 2017 weighted criteria compared to the 1997. In an early sle cohort the acr1997, slicc2012 and eular. The use of slicc and acr criteria to correctly label. The new 2019 eularacr classification criteria for sle requires a positive ana as obligatory entry criterion. To develop new classification criteria for systemic lupus erythematosus sle jointly supported by the european league against rheumatism eular and the american college of rheumatology acr. Systemic lupus erythematosus larissa lisnevskaia, grainne murphy, david isenberg systemic lupus erythematosus is a remarkable and challenging disorder. The diagnostic accuracies of the 2012 slicc criteria and the. In 2012, the systemic lupus international collaborating clinics slicc 12 published a new set. New sle classification criteria reset disease definition.
Reprinted with permission from bertsias gk, salmon je, boumpas dt. These criteria were developed and validated for the classification of patients with a longstanding established disease. Pdf performance of the new slicc classification criteria in. Pdf 2015 acrslicc revised criteria for diagnosis of systemic. American college of rheumatology classification criteria for. Pdf 2015 acrslicc revised criteria for diagnosis of. In 2012, the slicc criteria were published in an attempt to improve clinical relevance of sle criteria. The aim of this study was to compare the sensitivities of acr and slicc criteria in childhoodonset sle csle using a large, multiethnic cohort. Slicc acr damage index 1996 american college of rheumatology. The 2012 revised slicc criteria for classification of. In an early sle cohort the acr1997, slicc2012 and eularacr. New classification criteria for systemic lupus erythematosus.
Systemic lupus international collaborating clinics slicc criteria. Systemic lupus diagnostic criteria slicc calculator. Figure 1 natural history of systemic lupus erythematosus. The reliability of the systemic lupus international collaborating clinicsamerican college of rheumatology damage. This study aimed to compare these criteria with the wellestablished american college of rheumatology classification criteria acr1997 criteria in a national cohort of juvenileonset systemic lupus erythematosus jsle patients and evaluate how patients classification criteria evolved over time. Like many rheumatological diseases, systemic lupus erythematosus sle is difficult to diagnose owing to the constellation of findings required. Systemic lupus erythematosus sle is a multiorgan disease. Validation of new systemic lupus erythematosus classification. Derivation and validation of the systemic lupus international collaborating clinics classification criteria for systemic lupus erythematosus. I offer a mnemonic that contains the 11 categories used by the american college of rheumatology,1from which four or more must be present to diagnose sle.
Slicc is dedicated to generating new knowledge in the field of lupus, and translating these basic and clinical research discoveries into better health care practices and policies to help provide a healthier future for people diagnosed with lupus. Systemic lupus erythematosus, sle, sle nephritis, sle management, sle classification, acr vs slicc criteria, new drugs in sle. Objective sle is traditionally classified using the american college of rheumatology acr criteria. Evaluation of the slicc classification criteria in patients with. Pdf version slicc classification criteria for sle amith balachandran, department of anaesthesia, cmc vellore, and ashish jacob mathew, assistant professor, department of rheumatology, cmc, vellore. American college of rheumatology acr and systemic lupus international collaborating clinics slicc. The recent used diagnostic criteria widely used for sle is 2015 acr slicc revised criteria for diagnosis of systemic lupus erythematosus which is based on point systems. Objective currently there are 2 different classification criteria for systemic lupus erythematosus sle. About 20% of the cases begin before the age of 16 years, being classified as juvenileonset systemic. Healthdayneither the american college of rheumatology acr nor the systemic lupus international collaborating clinics slicc criteria distinguishes patients with. Oct 22, 2015 pdf version slicc classification criteria for sle amith balachandran, department of anaesthesia, cmc vellore, and ashish jacob mathew, assistant professor, department of rheumatology, cmc, vellore. The systemic lupus erythematosus international collaborating clinics slicc group has recently proposed a revised classification criteria,10 which hopes to replace the 1997 american college of rheumatology criteria,11 to improve on the sensitivity and specificity table 1. The american college of rheumatology has 11 classification criteria for lupus.
We compared the european league against rheumatism eularamerican college of rheumatology acr2019, systemic lupus international collaborating clinics slicc 2012 and acr1997 criteria in an early median 48 months systemic lupus erythematosus sle cohort. The slicc 2012 sle classification criteria and the. These criteria are useful and give consistency in the. Some slicc criteria could not be applied some acute and chronic forms of cutaneous lupus, nonscarring alopecia, mononeuritis multiplex and complement values. Projects generally focus on classification, response, and remission criteria. Sliccacr criteria dont id severe internal disease in scle. Although the outlook for patients with sle has greatly improved, many unmet needs remain, chief of which is the development of safer and more efficacious therapies. Systemic lupus erythematosus sle is a chronic inflammatory disease affecting a number of organs and organ systems 1,2. Therapeutic opportunities in systemic lupus erythematosus. The acr has previously endorsed diagnostic criteria. Edi hidayat free download as powerpoint presentation.
The acr 1997 criteria were criticized for their suboptimal sensitivity. The slicc criteria are validated criteria for making the diagnosis of lupus. A comparison of three classification criteria sets for. We compared groups of patients based on whether the slicc criteria were met before. Validation of proposed eularacr sle classification criteria. We compared groups of patients based on whether the slicc criteria were met before, at the same time or after the acr were met. Another important aspect of the new slicc classification criteria is that biopsyproven lupus nephritis, in the presence of antinuclear or antidoublestrandeddna antibodies, is now sufficient. Slicc classification criteria for sle current medical. Criteria are cumulative and need not be present concurrently. Slicc criteria for sle slicc classification criteria for. This study examined large cohorts of subjects with sle and incomplete lupus erythematosus ile to compare the impact of acr and slicc criteria.
Systemic lupus erythematosus is a multiorgan system autoimmune disease with clinical and serological heterogeneity. We compared the ability of the american college of rheumatology acr, systemic lupus erythematosus international collaborating clinics slicc and european league against rheumatism eularacr systemic lupus erythematosus sle classification criteria sets to provide information regarding organ damage and mortality, over a 10. The formulation of initial criteria for sle was first proposed by the american college of rheumatology and appeared in 1971. Comparison among acr1997, slicc and the new eularacr. According to the slicc rule for the classification of sle, the patient must satisfy at least 4 criteria.
Different classification criteria for systemic lupus erythematosus sle have been proposed over many years. If a patient meets at least four criteria, lupus can be diagnosed with 95% specificity and 85% sensitivity. The slicc criteria for sle classification requires. Performance of the new slicc classification criteria in childhood systemic lupus erythematosus. The systemic lupus international collaborating clinics slicc. Other criteria were chosen from 7 clinical constitutional, hematologic, neuropsychiatric, mucocutaneous, serosal, musculoskeletal, renal and 3 immunologic antiphospholipid antibodies, complement proteins, slespecific antibodies categories, and weighted from 2 to 10.
A comparison of three classification criteria sets for systemic lupus erythematosus a study looking at links to outcome and mortality. The systemic lupus international collaborating clinics. The most widely used and accepted criteria has been the 1997 acr criteria. Background systemic lupus erythematosus sle is a disease with an autoimmune origin, which occurs nine times more often. Slicc, systemic lupus international collaborating clinicsamerican college of rheumatology damage index. Discoid rash raised erythematous patches with keratotic scaling, follicular plugging, and atrophic scarring 3. Apr 27, 2016 healthdayneither the american college of rheumatology acr nor the systemic lupus international collaborating clinics slicc criteria distinguishes patients with subacute cutaneous lupus.
Methods patients who had undergone avise ctd testing were assessed for sle diagnosis by the systemic lupus international collaborating clinics slicc and american college of rheumatology criteria and for sle damage by the systemic lupus international collaborating clinics damage index sdi at the time of avise testing t0 and 2 years later t2. Alternative methods for sle classification have been developed predominantly in adults, such as the slicc systemic lupus international. However, they have become widely used as diagnostic criteria in clinical situations. We found that slicc 12 is the classification criterion for sle presenting the. Background systemic lupus erythematosus sle is a disease with an autoimmune origin, which occurs nine times more often in women than in men, and is especially prevalent among women of. Apr 26, 2014 systemic lupus erythematosus sle is a chronic inflammatory disease affecting a number of organs and organ systems 1,2. Download pdf open epub full article content list abstract.
The acr supports criteria development projects in different topic areas related to rheumatic disease. The american college of rheumatology acr classification criteria for lupus and systemic lupus international collaborating clinics slicc criteria are designed to classify disease. Classification criteria for systemic lupus erythematosus michelle petri, 1anamaria orbai. Acrarhp annual meeting 20152009 meetings download abstracts. Derivation and validation of the systemic lupus international. Slicc 12, the new set of criteria established in 2012 to. Systemic lupus international collaborating clinics classification criteria for systemic lupus erythematosus michelle petri, 1anamaria orbai, graciela s. I offer a mnemonic that contains the 11 categories used by the american college. Toward new criteria for systemic lupus erythematosusa. Use of slicc criteria in a large, diverse lupus registry. State the classification criteria of lupus and their limitations when used for diagnostic purposes.
Toward new criteria for systemic lupus erythematosusa standpoint. The heterogeneity of systemic lupus erythematosus sle, long recognised by clinicians, is now challenging the entire lupus community, from geneticists to clinical investigators. Slicc classification criteria for sle amith balachandran, department of anaesthesia, cmc vellore, and ashish jacob mathew, assistant professor, department of rheumatology, cmc, vellore. The recent used diagnostic criteria widely used for sle is 2015 acrslicc revised criteria for diagnosis of systemic lupus erythematosus which is based on point systems. Novel paradigms in systemic lupus erythematosus the lancet. Conclusions the slicc criteria classify more subjects with sle than acr. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising.
Slicc criteria for sle slicc classification criteria for sle. Sliccnew criteria of systemic lupus erythematosus journal introduction systemic lupus erythematosus. In this classification, biopsyconfirmed lupus nephritis with positive antinuclear or antidoublestranded dna antibodies became a standalone criterion. Background systemic lupus erythematosus sle is a disease with an autoimmune origin, which occurs nine times more often in women than in men, and is especially. Jul 14, 2014 the most recent addendum to the classification criteria for sle dates from 2012, when the systemic lupus international collaborating clinics slicc group published a revision and validation of the acr criteria 5. Feb 08, 2016 systemic lupus erythematosus, sle, sle nephritis, sle management, sle classification, acr vs slicc criteria, new drugs in sle. Background systemic lupus erythematosus sle is a disease with an autoimmune origin, which occurs nine times more often in women than in men, and. Pdf the systemic lupus international collaborating clinics slicc group revised and validated. To date there are no specific classification criteria for childhoodonset systemic lupus erythematosus csle. Patients may be labelled as systemic lupus erythematosus sle in their medical records, when in fact they have cutaneous lupus. However, our patient met the acr criteria for sle which has a sensitivity of 85% and specificity of 95%11 as he had arthralgias, pleural and pericardial effusions, lymphopenia and raised antidsdna, and met 5 out of 11 criteria according to newer systemic lupus international collaboration clinics criteria slicc criteria due to decreased. A list of items considered to reflect damage in sle was generated through a nominal group from the systemic lupus international collaborating clin ics slicc and the american college of rheumatology diagnostic and therapeutic criteria committee. Diagnostic criteria for systemic lupus erythematosus. Systemic lupus international collaborating clinics.
We compared the european league against rheumatism eularamerican college of rheumatology acr2019, systemic lupus international collaborating clinics slicc2012 and acr1997 criteria in an early median 48 months systemic lupus erythematosus sle cohort. Validation of the 2017 weighted criteria compared to the. In the text below the form there is information on the slicc, along with instructions on how to interpret the criteria that is present. A mnemonic for sle diagnostic criteria annals of the. This systemic lupus diagnostic criteria slicc calculator helps the classification and diagnosis of sle based on clinical and immunological criteria. Using the data up to v0, we determined the dates at which the acr and slicc criteria were first met. The systemic lupus international collaborating clinics slicc recently validated an alternative system. Wallace,8 ola nived,9 gunnar sturfelt,9 rosalind ramseygoldman,10 sangcheol bae,11. Pdf derivation and validation of the systemic lupus international. Objectives classification criteria are biased towards classifying longstanding disease. Slicc12, the new set of criteria established in 2012 to. The 2012 systemic lupus international collaborating clin ics slicc classification criteria addressed many of these issues. Slicc criteria but the 2015 acr slicc revised criteria can.
Download as pptx, pdf, txt or read online from scribd. Correct classification of patients with systemic lupus erythematosus sle is critical for clinical trials and clinical and translational science. The use of slicc and acr criteria to correctly label patients. In the validation set, the slicc classification criteria resulted in fewer misclassifications compared with the current acr classification criteria 62 versus 74. We included 56 confirmed sle cases meeting the 1982 acr criteria. Because of the unknown diagnostic performance among patients from nephrology clinics, we aimed to. Use of slicc criteria in a large, diverse lupus registry enables sle. Study evaluates slicc12 classification criteria for lupus. New eularacr classification criteria for sle rheumnow. Patients may be labelled as systemic lupus erythematosus sle in their medical records, when in fact they have. Its diversity of clinical features is matched by the complexity of the factors genetic, hormonal, and environmental that cause it, and the array of autoantibodies with which it is associated.
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